Arteries From Normal and Cholesterol-Fed Rabbits In Vivo Gene Transfer of Nitric Oxide Synthase Enhances Vasomotor Function in Carotid
نویسندگان
چکیده
Olmez, Geetha A. Shetty, Scot A. Youngblood, John Pawloski, Timothy McMahon, Jonathan S. Keith M. Channon, HuSheng Qian, Valentina Neplioueva, Michael A. Blazing, Ercument Arteries From Normal and Cholesterol-Fed Rabbits In Vivo Gene Transfer of Nitric Oxide Synthase Enhances Vasomotor Function in Carotid Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.98.18.1905 1998;98:1905-1911 Circulation. http://circ.ahajournals.org/content/98/18/1905 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-Fed rabbits.
BACKGROUND The vascular endothelium is anatomically intact but functionally abnormal in preatherosclerotic states, and an early deficit in the bioavailability of nitric oxide (NO) or related molecules has been described in both humans and animal models. We hypothesized that the targeted gene transfer of NO synthase (NOS) isoforms might ameliorate or reverse the deficit. METHODS AND RESULTS We...
متن کاملIn vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits enhances endothelium-dependent relaxations.
BACKGROUND AND PURPOSE Hypercholesterolemia is associated with abnormal endothelium-dependent vasorelaxation due to decreased nitric oxide bioavailability. Our aim was to examine the effect of adenovirus-mediated gene transfer of endothelial nitric oxide synthase (eNOS) to the hypercholesterolemic rabbit carotid artery in vivo. In addition, we examined whether adenovirus-mediated gene transfer ...
متن کاملIn vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits.
BACKGROUND AND PURPOSE Hypercholesterolemia is associated with endothelial dysfunction. Inducible nitric oxide synthase (iNOS) is upregulated in atherosclerotic vessels. However, its role in the regulation of vascular function is not completely understood. We examined the effect of adenovirus-mediated gene transfer of iNOS to the hypercholesterolemic rabbit carotid artery in vivo. METHODS Rab...
متن کاملNitric oxide synthase gene therapy rapidly reduces adhesion molecule expression and inflammatory cell infiltration in carotid arteries of cholesterol-fed rabbits.
BACKGROUND Hypercholesterolemia reduces nitric oxide bioavailability, manifested by reduced endothelium-dependent vascular relaxation, and also induces vascular adhesion molecule expression and inflammatory cell infiltration. We have previously shown that gene therapy with NO synthase in hypercholesterolemic rabbits substantially reverses the deficit in vascular relaxation. In the present study...
متن کاملImprovement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase.
Gene transfer with replication-deficient adenovirus is a useful tool to study vascular biology. We have reported that overexpression of endothelial nitric oxide (NO) in carotid arteries from normal rabbits augments vasorelaxation mediated by NO. In this study, we tested the hypothesis that adenovirus-mediated gene transfer of endothelial nitric oxide synthase (eNOS) improves impaired relaxation...
متن کامل